To study single molecules, Block has pioneered the use of optical tweezers, tiny laser-based "tractor beams" that produce miniscule piconewton forces to drag around molecules and allow measurements of displacements on the order of a nanometer. "You can stop and stall molecules, w follow their motion. Recently, we've studied the backtracking of RNA polymerase: when it makes a mistake, it can actually back up by five bases, scoop off the wrong thing and start again," says Block. While biological nanotechnology "hasn't even arrived at its infancy yet," says Block, "biological nanoscience is a very exciting place to be right now, because the techniques now exist to truly study proteins, and we're learning so much about them."








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It's easy to define and describe a nanometer: a nanometer is a billionth of a meter. That's a millionth of a pinhead, a thousandth of a red blood cell diameter, or the length of a line of ten hydrogen atoms rubbing shoulders. If only knowing what nanotechnology really means were as simple: "Have you heard the story of the elephant and the blind man?" Professor Krishna Saraswat chuckles. "Nanotechnology has different meanings to different people, but the conventional definition is the science of material patterned at the 1-100 nm length scale," notes Professor Michael McGehee. Professor Chris Chidsey muses, "Nanotechnology is a concept that is largely designed to capture people's imagination rather than describe a particular type of research. It's largely an attempt to portray a unified vision for a pretty wide-ranging group of activities that might not otherwise get recognized."
18 Stanford Scientific Review successfully demonstrated their use as highly sensitive toxic gas sensors, and with Professor Calvin Quate (Electrical Engineering), has commercialized nanotubes as scanning probe tips to increase probe resolution and tip durability. An area that Dai has just begun exploring is the drug delivery potential of carbon nanotubes. "The tube has a large surface area and is empty inside. So either you can attach the drug to the outer surface, or fill it up like a test tube," says Dai. Furthermore, multiple functional molecules can be attached to the surface: "Say, a molecule that fluoresces to tell you where the drug is in the cell and an antibody that specifically targets the site of drug delivery." So far, Dai reports that his research finds nanotubes to be quite "biologically friendly."